Virgil was pretty friendly with everyone before the outbreak, though very distrusting which showed. He would attend get-togethers when invited and was all around fairly charismatic. He also had a few friends, which can be your characters if you wish, but he knew that they thought he was off. Virgil would often try to show people his "truth" which consisted of conspiracies about Necromorph outbreaks on Aegis VII and Titan Station, but most people dismissed him as paranoid. Turns out he was right about the whole Necromorph things, so it works out.
So, if anyone wants to have a connection to Virgil, or through him, go for it.