Re: Shadow Runners
For vampires I usually play like this, decapitation is enough, when heart is pierced even by regular objects they are imobilised.
I rather treat them as a species than an unholy creature so holy stuff as no use, but magic damage works, but you're the vamp, let's do it your way, just shouting out ideas.
I also like to play that when a vamp dies it ashes, the ashes fly in the wind and end up together in the place where it's body was buried, that the ammount of times of people the vamp killed before he turned, that's why Dracula is hard to kill, he murdered between 20.000 and 500.000 people.
Werewolves:
Thick skin can only be pierced with magic, or silver, regular silver burns/hurts them but can't do much, a silver blade or bullet will scar them for life, hit the heart it dies, hit the brain it becomes a savage beast totally out of control (they have very few control by their human side before they get head shots).
magic can hurt them but hardly kill unless it's a really strong spell (for example small fire balls can only hurt but won't pierce the skin, a large fire ball, the size of a truck will burn it to ashes.)
Zombies:
destroy the connection between brain and heart or either of those parts.
Warlocks:
They are as vulnerable as humans but cast lots of protective spells, wear their magic off with a fight and proceed with th execution.
Ghosts:
Some non physical spells may work, but usually we must solve thir pending matters and help them cross over.
I can't think of more right now, but give me a list of creatures we will fight and I'll provide the means to kill it.