Based on this discussion of spiritual power, Runa probably wouldn't be able to notice any ghosts at all. Her theme is pretty much pure physical ability, so she's really got no outstanding spiritual ability beyond that of a normal person.
I'm not sure if Sophia would notice or not. She might sometimes get a feeling of a presence of some sort, if only to fuel paranoia and so-on. I'm not sure if Gifted ESPer style powers would count for high spiritual potential or not. (And, anyway, cybernetics often eat your soul, artificially reducing such ability.)