I'd probably go for a mix of both. I'd want to focus more on the show than the comics, just to keep things a little more contained overall. Maybe stretch things out to the entire DC Animated Universe? I know that Teen Titans isn't technically a part of that, but I feel like it could be incorporated with only a little canon bending. I think I'd want to have OCs serve as main characters, with canon heroes and villains serving as either mentor figures or BBEGs respectively. Not that they couldn't be involved, just that they won't have full main stage.