I'm undecided on the plot for the moment, however I think I will leave it to a group vote. Since I feel dead and exhausted I won't go into much detail.
1: The Lycans in this RP were created by gene splicing, and were designed to be used in war. They escaped and are now on the run.
2: This idea is similar to the first, however the Lycans become so by a form of terrorist attack. A portion of the US becomes infected and a city wide quarantine take effect. The goal of this plot is to simply either fight back, survive, or flee the city.
3: This RP will more or less take place after plot #2. War eventually erupts between the quarantine Lycans and the US government. The economy crashes, the government collapses, and total anarchy rules the states. Cities become abandoned, humans turn on each other waging war, and the Lycans retreat into the more uninhabited regions of the US. The Lycans create a life for themselves away from human kind. Eventually however the humans began to organize and rebuild, yet it is not an easy task. The threat in another war between the Lycans and what humans remain is still a possibility.
These are my ideas, they may not be glamorous but like I said I've been ran ragged these past few days and have not put a lot of thought into it. Let me now if anyone has questions or ideas of their own.