1st thing you think of...

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a blue frowning face with a small tear rolling down it's cheek.
 
Someone who forgot that they need oxygen to breathe and are crying because they are too stupid to exhale...
 
People who go from low to high altitudes and forget the oxygen level drops.
 
Air being ripped from your lungs in outer space.
 
Yogscast Sjin's avatar in the game Spacemen. His avatar looked like a pixilated astronaut in an orange space suit.