Asthma's one, though really it hasn't been as much of a bother for me as it is for other people who have it. I've never needed an inhaler, for one, nor have I ever had an asthma attack, both of which tends to make people skeptical as to whether I actually have Asthma or that I'm just making it up, which is annoying to say the least. Though when I was little I did have to used this machine that made me inhale some medicine into my lungs, I only vaguely remember it; I think we still have it in the house somewhere, though I don't need it anymore. Nowadays all Asthma means for me is that I have extremely low endurance such that I can barely even run for more than minute, used to be a lot worse than that lemme tell you.
I also have ADHD, which is a real pain I must say. I was diagnosed in 6th grade when my grades were at a all time low, the doctor prescribed me pills to take and I absolutely hated it. I didn't want to admit that I needed them, that there was something wrong with my brain to the point that I need medication to function properly. For a good while I refused to take them, and that caused problems, so I eventually just sucked up my pride and took those stupid pills, it was straight A's after that. But that glory didn't really last that long, as my body quickly built up an immunity to them after the first year or so, once I realized this I stopped bothering with the meds and now I'm back into the struggle of staying focused. I might have "grown out of it" a little bit, but it's there and still a problem, sometimes I lose focus so badly that I can't even focus my eyes and my vision goes blurry for a few moments without me even realizing, those moments are the worst. Also I make at least 50 fifty mistakes in everything I write because. Brain. Can't. Focus. For. Long. And have to go back and proofread like a billion times, and even then I only ever notice a small amount of my mistakes until much later. So if you see a lot of typos in any of my posts, including this one, that's why.
There's also defect with my body that I've had since birth, but I was kept in the dark about it up until my teen years when I was old enough to actually understand the implications of said defect. I won't go into too much detail because it's a rather TMI (you can kinda guess what it is anyways), but basically what it means that my body can't enough produce testosterone on it's own to satisfy the need for it. So at some point during high school I had no choice but to start getting monthly shots of testosterone to make up for the lack thereof, without them, I wouldn't even have be able to go through puberty. Even so, it's not a very good substitute and doesn't complete fulfill my body's needs. Also, aside from the inability to produce a key male hormone, this birth defect makes it very likely that I won't ever be able to have kids. Talk about a missed opportunity, before I'm even old enough to make such a decision, I find out that I never had the luxury to choose to begin with... Good thing there's always adoption.
Oh, yeah, and I have bad eyesight, but like Minibit said I wasn't born with it.